Cerebral Blood Flow and Metabolism in Pernicious Anemia

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Cerebral blood flow and metabolism in pernicious anemia.

P EIiNICIOUS ANEMIA is a deficiency disease which involves the metabolism of at least the hematologic, gastiointestinal and nervous systems. Signs and symptoms occurring from the disease may result directly from the effects of the deficiency on cell metabolism or more indirectly l)ecause of the anemia. The tongue and nervous system may he involved with little or no cvidence of hematologic disea...

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The Metabolism of Blood Pigments in Pernicious Anemia.

Pernicious anemia is believed at present to be caused by a simple deficiency of a substance which is required specifically for the maturation of erythropoietic cells (1). For a considerable period however, up to the discovery of the curative effect of liver, the disease was supposed commonly to be a hemolytic anemia. Recent developments in the study of the metabolism of the respiratory pigments...

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Cerebral Blood Flow Physiology and Metabolism

The brain comprises only 2% of total body weight; however, under normal conditions, it receives 15–20% of the cardiac output and accounts for 20% of total body oxygen consumption. Because energy reserves within the brain are negligible, adequate blood flow is essential for the provision of a continuous supply of energy-producing substrates and for the removal of the byproducts of cellular metab...

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5 Brain metabolism and cerebral blood flow

Cerebral blood flow is influenced and regulated by a number of factors, including arterial blood pressure, intracranial pressure, venous outflow, blood viscosity, PaCO2 and PaO2, collateral flow, vasoreactivity and the status of cerebral autoregulation. The regulation of vascular resistance lies mainly in the arterioles and precapillary segments (Auer and Loew, 1983). It is important to note th...

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ژورنال

عنوان ژورنال: Blood

سال: 1951

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v6.3.213.213